Therapeutic Studies


A5324

Why are we doing the study Patients with HIV infection, despite doing very well on antiretroviral therapy have ongoing inflammation and an increased risk of complications including HIV-associated neurological disease that usually manifests with some difficulties with daily activities and memory loss. Within that the reason why some patients develop HIV associated neurocognitive impairment is...

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A5332

Why are we doing the study Patients with HIV infection, despite doing very well on antiretroviral therapy have ongoing inflammation and an increased cardiovascular risk, even if their cholesterol levels are normal. We think that by giving an statin, a drug to lower the cholesterol levels, we may be able to decrease the cardiovascular risk...

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A5336

Why are we doing the study Patients with HIV infection, despite doing very well on antiretroviral therapy have ongoing inflammation and an increased risk of complications associated with ongoing inflammation including higher cardiovascular risk, osteoporosis, metabolic problems, aging etc. We also think that the ongoing inflammation might be associated with the size of the HIV...

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A5354

Why are we doing the study After infection the HIV virus establishes the “HIV reservoir” very quickly. As time goes by this reservoir becomes bigger and it is almost impossible to eradicate even with potent antiretroviral therapy. That is why we have not been able to cure HIV so far. We think that if we...

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C34

Why are we doing the study We are trying to modify CD4 cells of patients with HIV infection to make them resistant to HIV and reinfuse them back. Attaching a protein (C34) to the CXCR4 receptor prevents the HIV virus to enter the cell in the test tube. Potential participants Patients with HIV infection doing...

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VRC01LS

Why are we doing the study Patients with HIV infection have to take medicines every day. We want to know if we can treat patients with HIV intermittently, so they do not have to take medicines every day. We want to know if broadly neutralizing antibodies, that are injected to the patients every few months,...

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